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Target
Growth hormone-releasing hormone receptor
Ligand
BDBM50403624
Substrate
n/a
Meas. Tech.
ChEBML_193173
EC50
1.5±n/a nM
Citation
 Tata, JR; Lu, Z; Jacks, TM; Schleim, KD; Cheng, K; Wei, L; Chan, WW; Butler, B; Tsou, N; Leung, K; Chiu, S; Hickey, G; Smith, RG; Patchett, AA The design and synthesis of orally active short duration spiroindane growth hormone secretagogues Bioorg Med Chem Lett 7:2319-2324 (1997)    Article 
Target
Name:
Growth hormone-releasing hormone receptor
Synonyms:
GHRH receptor | GHRHR_RAT | GRF receptor | Ghrhr | Grfr
Type:
PROTEIN
Mol. Mass.:
51523.38
Organism:
Rattus norvegicus
Description:
ChEMBL_193173
Residue:
464
Sequence:
MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
  
Inhibitor
Name:
BDBM50403624
Synonyms:
CHEMBL542653
Type:
Small organic molecule
Emp. Form.:
C27H36N4O5S
Mol. Mass.:
528.664
SMILES:
CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1 |r|
Structure:
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