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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50367014
Substrate
n/a
Meas. Tech.
ChEBML_89668
Ki
84000±n/a nM
Citation
 Skibo, EB; Meyer, RB Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides. J Med Chem 24:1155-61 (1982) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
IMDH_ECOLI | guaB | guaR
Type:
PROTEIN
Mol. Mass.:
52020.85
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_89670
Residue:
488
Sequence:
MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS
  
Inhibitor
Name:
BDBM50367014
Synonyms:
CHEMBL604182
Type:
Small organic molecule
Emp. Form.:
C18H22N5O8PS
Mol. Mass.:
499.435
SMILES:
COc1ccc(CSc2nc3c(N)ncnc3n2C2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)cc1 |r|
Structure:
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