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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50227961
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
195±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50227961
Synonyms:
CHEMBL2369784
Type:
Small organic molecule
Emp. Form.:
C48H71N11O9
Mol. Mass.:
946.1456
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 |wU:5.4,39.40,31.32,23.24,wD:51.53,12.13,(30.15,-15.5,;28.66,-15.12,;28.27,-13.61,;26.8,-13.23,;25.69,-14.31,;26.4,-11.72,;27.37,-10.53,;26.54,-9.25,;25.03,-9.63,;24.96,-11.17,;23.64,-10.4,;23.65,-8.86,;22.31,-11.17,;22.27,-12.71,;23.61,-13.5,;23.59,-15.04,;24.9,-15.83,;24.89,-17.37,;23.56,-18.1,;26.22,-18.14,;20.96,-10.37,;19.63,-11.17,;19.64,-12.71,;18.3,-10.4,;18.26,-8.86,;19.6,-8.09,;20.95,-8.83,;19.58,-6.55,;16.97,-11.2,;15.62,-10.44,;15.6,-8.9,;14.29,-11.21,;14.31,-12.75,;15.63,-13.52,;16.92,-12.65,;15.81,-15.04,;12.94,-10.44,;11.62,-11.24,;11.62,-12.78,;10.26,-10.47,;10.26,-8.93,;11.59,-8.15,;11.58,-6.61,;12.91,-5.82,;14.25,-6.59,;15.57,-5.81,;14.27,-8.13,;12.94,-8.9,;8.95,-11.24,;7.6,-10.5,;7.58,-8.96,;6.27,-11.29,;6.27,-12.81,;7.61,-13.58,;4.94,-10.52,;3.59,-11.3,;3.6,-12.84,;2.26,-10.53,;2.25,-8.99,;.91,-8.24,;-.5,-8.89,;-1.53,-7.74,;-.77,-6.39,;-1.25,-4.95,;-.25,-3.82,;1.26,-4.12,;1.74,-5.58,;.72,-6.72,)|
Structure:
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