Reaction Details Report a problem with these data
Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50227964
Substrate
n/a
Meas. Tech.
ChEMBL_100135 (CHEMBL712414)
Ki
123±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50227964
Synonyms:
CHEMBL2369780
Type:
Small organic molecule
Emp. Form.:
C49H73N11O9
Mol. Mass.:
960.1722
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 |wU:5.4,39.40,23.24,31.32,wD:51.53,12.13,(33.1,-17.97,;31.61,-17.59,;31.22,-16.08,;29.75,-15.7,;28.64,-16.78,;29.35,-14.19,;30.32,-13,;29.49,-11.72,;27.98,-12.1,;27.91,-13.64,;26.59,-12.87,;26.6,-11.33,;25.25,-13.64,;25.22,-15.18,;26.56,-15.97,;26.54,-17.51,;27.85,-18.29,;27.84,-19.83,;26.51,-20.57,;29.17,-20.6,;23.91,-12.84,;22.58,-13.64,;22.59,-15.18,;21.25,-12.87,;21.21,-11.33,;22.55,-10.56,;22.53,-9.02,;23.9,-11.3,;19.92,-13.66,;18.57,-12.91,;18.55,-11.37,;17.24,-13.68,;17.26,-15.22,;18.58,-15.98,;18.76,-17.51,;19.87,-15.12,;15.89,-12.93,;14.57,-13.71,;14.57,-15.25,;13.22,-12.94,;13.22,-11.4,;14.54,-10.6,;15.89,-11.37,;17.23,-10.6,;17.2,-9.06,;18.52,-8.28,;15.86,-8.29,;14.53,-9.08,;11.9,-13.73,;10.55,-12.97,;10.53,-11.43,;9.22,-13.76,;9.24,-15.28,;10.56,-16.05,;7.89,-12.99,;6.54,-13.77,;6.55,-15.31,;5.21,-13,;3.88,-13.79,;2.54,-13.03,;1.22,-13.8,;1.1,-15.34,;-.38,-15.73,;-1.21,-14.41,;-2.72,-14.16,;-3.23,-12.71,;-2.23,-11.53,;-.73,-11.8,;-.21,-13.25,)|
Structure:
Search PDB for entries with ligand similarity: