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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM50411573
Substrate
n/a
Meas. Tech.
ChEMBL_455564 (CHEMBL903551)
Ki
5300±n/a nM
Citation
 Mermerian, AH; Case, A; Stein, RL; Cuny, GD Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett 17:3729-32 (2007) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM50411573
Synonyms:
CHEMBL557989
Type:
Small organic molecule
Emp. Form.:
C16H12N2O5S
Mol. Mass.:
344.342
SMILES:
COc1ccccc1C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Structure:
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