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Target
C-C chemokine receptor type 8
Ligand
BDBM50423492
Substrate
n/a
Meas. Tech.
ChEMBL_465785 (CHEMBL948147)
IC50
12±n/a nM
Citation
 Shamovsky, I; Connolly, S; David, L; Ivanova, S; Nordén, B; Springthorpe, B; Urbahns, K Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships. J Med Chem 51:1162-78 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50423492
Synonyms:
CHEMBL409648
Type:
Small organic molecule
Emp. Form.:
C30H33ClN2O3
Mol. Mass.:
505.048
SMILES:
COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(CC3)C(=O)c2ccc(Cl)cc2)c1
Structure:
Search PDB for entries with ligand similarity: