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Target
Mas-related G-protein coupled receptor member X1
Ligand
BDBM50412989
Substrate
n/a
Meas. Tech.
ChEMBL_516621 (CHEMBL991397)
EC50
24±n/a nM
Citation
 Wroblowski, B; Wigglesworth, MJ; Szekeres, PG; Smith, GD; Rahman, SS; Nicholson, NH; Muir, AI; Hall, A; Heer, JP; Garland, SL; Coates, WJ The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor. J Med Chem 52:818-25 (2009) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4
Type:
PROTEIN
Mol. Mass.:
36253.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_516621
Residue:
322
Sequence:
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
  
Inhibitor
Name:
BDBM50412989
Synonyms:
CHEMBL474473
Type:
Small organic molecule
Emp. Form.:
C29H29ClN6O3
Mol. Mass.:
545.032
SMILES:
COc1ccc(cn1)-c1ccc(cc1)C(=O)Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1C
Structure:
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