Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50216395
Substrate
n/a
Meas. Tech.
ChEMBL_574503 (CHEMBL1030342)
IC50
12.59±n/a nM
Citation
 Guile, SD; Alcaraz, L; Birkinshaw, TN; Bowers, KC; Ebden, MR; Furber, M; Stocks, MJ Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem 52:3123-41 (2009) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50216395
Synonyms:
CHEMBL231032 | N-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)isoquinoline-5-sulfonamide | isoquinolinesulfon-5-yl-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl}amide
Type:
Small organic molecule
Emp. Form.:
C21H21FN4O3S
Mol. Mass.:
428.48
SMILES:
Fc1ccccc1N1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2cnccc12
Structure:
Search PDB for entries with ligand similarity: