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Target
D(3) dopamine receptor
Ligand
BDBM50411402
Substrate
n/a
Meas. Tech.
ChEMBL_582203 (CHEMBL1059863)
Ki
1.58±n/a nM
Citation
 Holmes, IP; Micheli, F; Gaines, S; Lorthioir, O; Watson, SP; Fabio, RD; Gentile, G; Heidbreder, C; Savoia, C; Worby, A Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. Bioorg Med Chem Lett 19:4799-801 (2009) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50411402
Synonyms:
CHEMBL244946
Type:
Small organic molecule
Emp. Form.:
C31H35N7S
Mol. Mass.:
537.722
SMILES:
Cc1cc(-c2ccc3CCN(CCCSc4nnc(-c5cccc6nc(C)ccc56)n4C)CCc3c2)n(C)n1
Structure:
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