Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50385682
Substrate
n/a
Meas. Tech.
ChEMBL_605175 (CHEMBL1067397)
Ki
11481.54±n/a nM
Citation
 Piergentili, A; Quaglia, W; Del Bello, F; Giannella, M; Pigini, M; Barocelli, E; Bertoni, S; Matucci, R; Nesi, M; Bruni, B; Di Vaira, M Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. Bioorg Med Chem 17:8174-85 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50385682
Synonyms:
CHEMBL390842
Type:
Small organic molecule
Emp. Form.:
C9H20NO2
Mol. Mass.:
174.2601
SMILES:
C[C@H]1COC[C@@H](C[N+](C)(C)C)O1 |r|
Structure:
Search PDB for entries with ligand similarity: