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Target
Histamine H2 receptor
Ligand
BDBM50415637
Substrate
n/a
Meas. Tech.
ChEMBL_621959 (CHEMBL1104101)
EC50
1995.26±n/a nM
Citation
 Igel, P; Geyer, R; Strasser, A; Dove, S; Seifert, R; Buschauer, A Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem 52:6297-313 (2009) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50415637
Synonyms:
CHEMBL1078358 | UR-PI97
Type:
Small organic molecule
Emp. Form.:
C16H22N6O
Mol. Mass.:
314.3855
SMILES:
NC(=O)NC(NCCCc1ccccc1)=NCCc1cnc[nH]1 |w:15.16|
Structure:
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