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Target
Egl nine homolog 1
Ligand
BDBM50418034
Substrate
n/a
Meas. Tech.
ChEMBL_730288 (CHEMBL1696528)
IC50
12589.25±n/a nM
Citation
 Rosen, MD; Venkatesan, H; Peltier, HM; Bembenek, SD; Kanelakis, KC; Zhao, LX; Leonard, BE; Hocutt, FM; Wu, X; Palomino, HL; Brondstetter, TI; Haugh, PV; Cagnon, L; Yan, W; Liotta, LA; Young, A; Mirzadegan, T; Shankley, NP; Barrett, TD; Rabinowitz, MH Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Med Chem Lett 1:526-529 (2010) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50418034
Synonyms:
CHEMBL1230217
Type:
Small organic molecule
Emp. Form.:
C10H7Cl2N3O3
Mol. Mass.:
288.087
SMILES:
OC(=O)CNC(=O)c1nc2cc(Cl)c(Cl)cc2[nH]1
Structure:
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