Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50325824
Substrate
n/a
Meas. Tech.
ChEMBL_838179 (CHEMBL2076651)
Ki
275000±n/a nM
Citation
 Bakhiya, A; Bahn, A; Burckhardt, G; Wolff, N Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem 13:249-56 (2003) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3
Type:
PROTEIN
Mol. Mass.:
59870.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1486920
Residue:
542
Sequence:
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
  
Inhibitor
Name:
BDBM50325824
Synonyms:
1H-purine-2,6,8(3H,7H,9H)-trione | 7,9-Dihydro-3H-purine-2,6,8-trione | 7,9-Dihydro-3H-purine-2,6,8-trione(Urate) | 7,9-Dihydro-3H-purine-2,6,8-trione(uric acid) | CHEMBL792 | URIC ACID
Type:
Small organic molecule
Emp. Form.:
C5H4N4O3
Mol. Mass.:
168.1103
SMILES:
O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1
Structure:
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