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Target
Solute carrier organic anion transporter family member 1A3
Ligand
BDBM50391007
Substrate
n/a
Meas. Tech.
ChEMBL_838743 (CHEMBL2078569)
Ki
1200±n/a nM
Citation
 Takeuchi, A; Masuda, S; Saito, H; Hashimoto, Y; Inui, K Trans-stimulation effects of folic acid derivatives on methotrexate transport by rat renal organic anion transporter, OAT-K1. J Pharmacol Exp Ther 293:1034-9 (2000) [PubMed] 
Target
Name:
Solute carrier organic anion transporter family member 1A3
Synonyms:
OAT-K1 | OAT-K2 | Oatp1a3 | SO1A3_RAT | Slc21a4 | Slco1a3 | Sodium-independent organic anion transporter K1 | Solute carrier family 21 member 4 | rOAT-K
Type:
PROTEIN
Mol. Mass.:
73829.31
Organism:
Rattus norvegicus
Description:
ChEMBL_838743
Residue:
670
Sequence:
MGDLEKGAATHGAGCFAKIKVFLMALTCAYVSKSLSGTFMSSMLTQIERQFGIPTAIVGFINGSFEIGNLLLIIFVSYFGMKLHRPIVIGVGCAVMGLGCFIISLPHFLMGRYEYETTILPTSNLSSNSFLCMENQTQTLNPAQDPAECVKEVKSLMWIYVLVGNIIRGIGETPIMPLGVSYIENFAKSENSPLYIGILETGKMIGPIFGLLLGSFCASIYVDTGSVNTDDLTITPTDIRWVGAWWIGFLVCAGVNILISIPFFFFPKTLPKEGLQENVDGTENAKEESTEKRPRKKNRGITKDFFPFLKSPVLQPDLHAVHPYKVLQVNAFNIYFSFLPKYLENQYGKSTAEVIFLMGVYNLPAICIGYLIAGFMMKKFKITVKTAAFLAFCLSLSEYSFGFCNFLITCDNVPVAGLTNSYERDQKPLYLENNVLADCNTRCSCLTKTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFHNCSCIQSPGNSSAVLGLCNKGPECTNKLQYLLILSGFLSILYSFAAIPGYMVFLRCIKSEEKSLGIGIHAFCIRVFAGIPAPIYFGALIDRTCLHWGTQKCGAPGACRMYDINSFRRIYLGMSAALRGSSYLPAFVIVILTRKFSLPGKINSSEMEIAEMKLTEKESQCTDVHRNPKFKNDGELKTKL
  
Inhibitor
Name:
BDBM50391007
Synonyms:
LEVOMEFOLIC ACID | LMSR
Type:
Small organic molecule
Emp. Form.:
C20H25N7O6
Mol. Mass.:
459.4558
SMILES:
CN1[C@@H](CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12 |r|
Structure:
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