Reaction Details Report a problem with these data
Target
Fibroblast growth factor 1
Ligand
BDBM50421301
Substrate
n/a
Meas. Tech.
ChEMBL_840110 (CHEMBL2090813)
Kd
243000±n/a nM
Citation
 Liu, L; Li, C; Cochran, S; Feder, D; Guddat, LW; Ferro, V A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorg Med Chem Lett 22:6190-4 (2012) [PubMed]  Article 
Target
Name:
Fibroblast growth factor 1
Synonyms:
Acidic fibroblast growth factor | Beta-endothelial cell growth factor | ECGF-beta | FGF1 | FGF1_HUMAN | FGFA | Fibroblast growth factor 1 (FGF-1) | HBGF-1 | Heparin-binding growth factor 1 | aFGF
Type:
Protein
Mol. Mass.:
17461.01
Organism:
Homo sapiens (Human)
Description:
P05230
Residue:
155
Sequence:
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
  
Inhibitor
Name:
BDBM50421301
Synonyms:
CHEMBL2087894
Type:
Small organic molecule
Emp. Form.:
C21H35N2O16S3
Mol. Mass.:
667.703
SMILES:
CCCCC1CCC(CC1)N(CC(=O)NC[C@H]1O[C@H](OC)[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)C(C)=O |r,wU:16.16,27.28,21.22,wD:33.35,18.19,(14.12,3.67,;12.79,2.9,;12.78,1.36,;11.45,.59,;11.45,-.95,;10.12,-1.73,;10.12,-3.27,;11.45,-4.03,;12.78,-3.27,;12.77,-1.73,;11.45,-5.57,;10.12,-6.33,;8.78,-5.56,;8.79,-4.02,;7.45,-6.32,;6.12,-5.55,;4.78,-6.32,;4.78,-7.86,;3.45,-8.62,;3.45,-10.16,;4.79,-10.93,;2.12,-7.86,;.79,-8.63,;.79,-10.17,;-.54,-10.94,;2.33,-10.17,;1.55,-11.5,;2.12,-6.32,;.79,-5.55,;-.54,-6.32,;-1.88,-5.56,;-1.32,-7.65,;.22,-7.65,;3.45,-5.54,;3.45,-4,;2.12,-3.23,;.78,-4,;1.34,-1.89,;2.88,-1.89,;12.78,-6.34,;12.78,-7.88,;14.12,-5.57,)|
Structure:
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