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Target
Histamine H1 receptor
Ligand
BDBM81471
Substrate
n/a
Meas. Tech.
ChEMBL_84547 (CHEMBL692983)
IC50
40±n/a nM
Citation
 Govoni, M; Bakker, RA; van de Wetering, I; Smit, MJ; Menge, WM; Timmerman, H; Elz, S; Schunack, W; Leurs, R Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. J Med Chem 46:5812-24 (2003) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM81471
Synonyms:
CAS_91-81-6 | NSC_5587 | Tripelennamine
Type:
Small organic molecule
Emp. Form.:
C16H21N3
Mol. Mass.:
255.358
SMILES:
CN(C)CCN(Cc1ccccc1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: