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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50422850
Substrate
n/a
Meas. Tech.
ChEMBL_339377 (CHEMBL867214)
IC50
331±n/a nM
Citation
 Di Fabio, R; Giovannini, R; Bertani, B; Borriello, M; Bozzoli, A; Donati, D; Falchi, A; Ghirlanda, D; Leslie, CP; Pecunioso, A; Rumboldt, G; Spada, S Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists. Bioorg Med Chem Lett 16:1749-52 (2006) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50422850
Synonyms:
CHEMBL206799
Type:
Small organic molecule
Emp. Form.:
C30H37ClN4O2
Mol. Mass.:
521.093
SMILES:
Clc1ccc(O[C@@H]2CC(N3CCNCC3)C(=O)c3c2n(CCCN2CCCCC2)c2ccccc32)cc1
Structure:
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