Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50424195
Substrate
n/a
Meas. Tech.
ChEMBL_933603 (CHEMBL2319987)
IC50
154±n/a nM
Citation
 Li, Y; Zhou, Y; Qian, P; Wang, Y; Jiang, F; Yao, Z; Hu, W; Zhao, Y; Li, S Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors. Bioorg Med Chem Lett 23:179-82 (2012) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50424195
Synonyms:
CHEMBL2312461
Type:
Small organic molecule
Emp. Form.:
C25H22N8O
Mol. Mass.:
450.4952
SMILES:
Nc1ccccc1NC(=O)c1ccc(CCNc2nccc(n2)-c2cnc3ncccn23)cc1
Structure:
Search PDB for entries with ligand similarity: