Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50424375
Substrate
n/a
Meas. Tech.
ChEMBL_935338 (CHEMBL2318649)
EC50
109±n/a nM
Citation
 Park, K; Lee, BM; Kim, YH; Han, T; Yi, W; Lee, DH; Choi, HH; Chong, W; Lee, CH Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett 23:537-42 (2012) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50424375
Synonyms:
CHEMBL2314799
Type:
Small organic molecule
Emp. Form.:
C23H23F2N3O3
Mol. Mass.:
427.4438
SMILES:
COC[C@H](C)Oc1cc(\C=C\c2ccc(F)cc2F)cc(c1)C(=O)Nc1ccn(C)n1 |r|
Structure:
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