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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50424727
Substrate
n/a
Meas. Tech.
ChEMBL_934323 (CHEMBL2320309)
Ki
5300±n/a nM
Citation
 Friberg, A; Vigil, D; Zhao, B; Daniels, RN; Burke, JP; Garcia-Barrantes, PM; Camper, D; Chauder, BA; Lee, T; Olejniczak, ET; Fesik, SW Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem 56:15-30 (2013) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50424727
Synonyms:
CHEMBL2314173 | US10093640, Example 2 | US10844032, Example 2
Type:
Small organic molecule
Emp. Form.:
C20H19ClO3S
Mol. Mass.:
374.881
SMILES:
Cc1cc(OCCCc2c(sc3ccccc23)C(O)=O)cc(C)c1Cl
Structure:
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