Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase A chain
Ligand
BDBM23222
Substrate
n/a
Meas. Tech.
ChEMBL_937563 (CHEMBL2320788)
Ki
26000±n/a nM
Citation
 Kohlmann, A; Zech, SG; Li, F; Zhou, T; Squillace, RM; Commodore, L; Greenfield, MT; Lu, X; Miller, DP; Huang, WS; Qi, J; Thomas, RM; Wang, Y; Zhang, S; Dodd, R; Liu, S; Xu, R; Xu, Y; Miret, JJ; Rivera, V; Clackson, T; Shakespeare, WC; Zhu, X; Dalgarno, DC Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J Med Chem 56:1023-40 (2013) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM23222
Synonyms:
Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Acid | carbamoylformic acid
Type:
Small organic molecule
Emp. Form.:
C2H3NO3
Mol. Mass.:
89.0501
SMILES:
NC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: