Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 22
Ligand
BDBM50425807
Substrate
n/a
Meas. Tech.
ChEMBL_937594 (CHEMBL2321063)
IC50
1400±n/a nM
Citation
 He, Y; Xu, J; Yu, ZH; Gunawan, AM; Wu, L; Wang, L; Zhang, ZY Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. J Med Chem 56:832-42 (2013) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 22
Synonyms:
DUS22_HUMAN | DUSP22 | Dual specificity phosphatase 22 | Dual specificity protein phosphatase (MKPX) | Dual specificity protein phosphatase 22 | Dual specificity protein phosphatase 22 (VHX) | Dual specificity protein phosphatase VHX (VHX) | JSP1 | LMWDSP2 | MKPX | Mitogen-activated protein kinase phosphatase x | VHX
Type:
Protein
Mol. Mass.:
20915.83
Organism:
Homo sapiens (Human)
Description:
Q9NRW4
Residue:
184
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
  
Inhibitor
Name:
BDBM50425807
Synonyms:
CHEMBL2316902
Type:
Small organic molecule
Emp. Form.:
C24H13F3O4
Mol. Mass.:
422.3528
SMILES:
OC(=O)c1cc2c(C#Cc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
Structure:
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