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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50426335
Substrate
n/a
Meas. Tech.
ChEMBL_939732 (CHEMBL2329085)
IC50
1200±n/a nM
Citation
 Myrianthopoulos, V; Kritsanida, M; Gaboriaud-Kolar, N; Magiatis, P; Ferandin, Y; Durieu, E; Lozach, O; Cappel, D; Soundararajan, M; Filippakopoulos, P; Sherman, W; Knapp, S; Meijer, L; Mikros, E; Skaltsounis, AL Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. ACS Med Chem Lett 4:22-26 (2013) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3
Type:
PROTEIN
Mol. Mass.:
46774.42
Organism:
Sus scrofa
Description:
ChEMBL_939732
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
  
Inhibitor
Name:
BDBM50426335
Synonyms:
CHEMBL2321878
Type:
Small organic molecule
Emp. Form.:
C18H10F3N3O4
Mol. Mass.:
389.2849
SMILES:
OC(=O)c1ccc2[nH]c(C3C(=O)Nc4c3cccc4C(F)(F)F)c(N=O)c2c1
Structure:
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