Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM50427695
Substrate
n/a
Meas. Tech.
ChEMBL_941878 (CHEMBL2329944)
IC50
2200±n/a nM
Citation
 Sassano, MF; Doak, AK; Roth, BL; Shoichet, BK Colloidal aggregation causes inhibition of G protein-coupled receptors. J Med Chem 56:2406-14 (2013) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50427695
Synonyms:
CHEMBL2324200
Type:
Small organic molecule
Emp. Form.:
C20H10I4O4
Mol. Mass.:
821.9089
SMILES:
Oc1cc(I)c(c(I)c1)C1(OC(=O)c2ccccc12)c1cc(I)c(O)c(I)c1
Structure:
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