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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50427874
Substrate
n/a
Meas. Tech.
ChEMBL_940855 (CHEMBL2330435)
IC50
>10000±n/a nM
Citation
 Lourido, S; Zhang, C; Lopez, MS; Tang, K; Barks, J; Wang, Q; Wildman, SA; Shokat, KM; Sibley, LD Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem 56:3068-77 (2013) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50427874
Synonyms:
CHEMBL2324596
Type:
Small organic molecule
Emp. Form.:
C13H12N4
Mol. Mass.:
224.2612
SMILES:
Cc1cccc(Cc2[nH]nc3ncncc23)c1
Structure:
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