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Target
WD repeat-containing protein 5
Ligand
BDBM50428263
Substrate
n/a
Meas. Tech.
ChEMBL_946433 (CHEMBL2339613)
Kd
6600±n/a nM
Citation
 Bolshan, Y; Getlik, M; Kuznetsova, E; Wasney, GA; Hajian, T; Poda, G; Nguyen, KT; Wu, H; Dombrovski, L; Dong, A; Senisterra, G; Schapira, M; Arrowsmith, CH; Brown, PJ; Al-Awar, R; Vedadi, M; Smil, D Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett 4:353-7 (2013) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50428263
Synonyms:
CHEMBL2337021
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O3
Mol. Mass.:
387.86
SMILES:
COC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2ccccc2Cl)c1
Structure:
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