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Target
Carbonic anhydrase 12
Ligand
BDBM50428489
Substrate
n/a
Meas. Tech.
ChEMBL_943469 (CHEMBL2342409)
Ki
0.980000±n/a nM
Citation
 Jogaite, V; Zubriene, A; Michailoviene, V; Gylyte, J; Morkunaite, V; Matulis, D Characterization of human carbonic anhydrase XII stability and inhibitor binding. Bioorg Med Chem 21:1431-6 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50428489
Synonyms:
CHEMBL2335191
Type:
Small organic molecule
Emp. Form.:
C14H14O3
Mol. Mass.:
230.2592
SMILES:
CCCc1ccc2ccc(=O)oc2c1C(C)=O
Structure:
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