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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50429094
Substrate
n/a
Meas. Tech.
ChEMBL_943194 (CHEMBL2346225)
IC50
59±n/a nM
Citation
 Hu, Y; Lin, EC; Pham, LM; Cajica, J; Amantea, CM; Okerberg, E; Brown, HE; Fraser, A; Du, L; Kohno, Y; Ishiyama, J; Kozarich, JW; Shreder, KR Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2. Bioorg Med Chem Lett 23:1553-6 (2013) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50429094
Synonyms:
CHEMBL2335783
Type:
Small organic molecule
Emp. Form.:
C18H16FN3O4S
Mol. Mass.:
389.401
SMILES:
Cc1cc(F)ccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1
Structure:
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