Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50430975
Substrate
n/a
Meas. Tech.
ChEMBL_947306 (CHEMBL2343612)
IC50
3105±n/a nM
Citation
 Patil, V; Sodji, QH; Kornacki, JR; Mrksich, M; Oyelere, AK 3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition. J Med Chem 56:3492-506 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50430975
Synonyms:
CHEMBL2337867
Type:
Small organic molecule
Emp. Form.:
C19H17NOS
Mol. Mass.:
307.409
SMILES:
Cc1ccccc1-c1ccc(Cn2cccc(O)c2=S)cc1
Structure:
Search PDB for entries with ligand similarity: