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Target
Proteasome subunit beta type-5
Ligand
BDBM50431000
Substrate
n/a
Meas. Tech.
ChEMBL_947322 (CHEMBL2343628)
IC50
79±n/a nM
Citation
 Kawamura, S; Unno, Y; List, A; Mizuno, A; Tanaka, M; Sasaki, T; Arisawa, M; Asai, A; Groll, M; Shuto, S Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action. J Med Chem 56:3689-700 (2013) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50431000
Synonyms:
CHEMBL2338307
Type:
Small organic molecule
Emp. Form.:
C25H33N3O5
Mol. Mass.:
455.5466
SMILES:
CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@H]1C[C@H](NC(=O)[C@H](C)NC(=O)c1ccccc1)C=C |r|
Structure:
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