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Target
High affinity immunoglobulin gamma Fc receptor I
Ligand
BDBM50432926
Substrate
n/a
Meas. Tech.
ChEMBL_957252 (CHEMBL2378869)
IC50
100±n/a nM
Citation
 Purohit, MK; Scovell, I; Neschadim, A; Katsman, Y; Branch, DR; Kotra, LP Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells. Bioorg Med Chem Lett 23:2324-7 (2013) [PubMed]  Article 
Target
Name:
High affinity immunoglobulin gamma Fc receptor I
Synonyms:
FCG1 | FCGR1 | FCGR1A | FCGR1_HUMAN | IGFR1
Type:
PROTEIN
Mol. Mass.:
42639.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446762
Residue:
374
Sequence:
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
  
Inhibitor
Name:
BDBM50432926
Synonyms:
CHEMBL2377172
Type:
Small organic molecule
Emp. Form.:
C20H18N4S2
Mol. Mass.:
378.514
SMILES:
Cc1cc(SSc2cc(C)nn2-c2ccccc2)n(n1)-c1ccccc1
Structure:
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