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Target
Sphingosine kinase 1
Ligand
BDBM50004888
Substrate
n/a
Meas. Tech.
ChEMBL_957869 (CHEMBL2378982)
Ki
10000±n/a nM
Citation
 Liu, Z; MacRitchie, N; Pyne, S; Pyne, NJ; Bittman, R Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorg Med Chem 21:2503-10 (2013) [PubMed]  Article 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM50004888
Synonyms:
(S)-Fingolimod Vinylphosphonate | CHEMBL1773676
Type:
Small organic molecule
Emp. Form.:
C20H34NO4P
Mol. Mass.:
383.462
SMILES:
CCCCCCCCc1ccc(CC[C@@](N)(CO)\C=C\P(O)(O)=O)cc1 |r|
Structure:
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