Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50433356
Substrate
n/a
Meas. Tech.
ChEMBL_955844 (CHEMBL2379701)
Ki
3162±n/a nM
Citation
 Andaloussi, M; Lim, HD; van der Meer, T; Sijm, M; Poulie, CB; de Esch, IJ; Leurs, R; Smits, RA A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett 23:2663-70 (2013) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50433356
Synonyms:
CHEMBL2376801
Type:
Small organic molecule
Emp. Form.:
C14H20N6
Mol. Mass.:
272.3488
SMILES:
CCc1cnc2c(nc(N)nc2c1)N1CC[C@H](C1)NC |r|
Structure:
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