Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50433359
Substrate
n/a
Meas. Tech.
ChEMBL_955840 (CHEMBL2379697)
Ki
15±n/a nM
Citation
 Andaloussi, M; Lim, HD; van der Meer, T; Sijm, M; Poulie, CB; de Esch, IJ; Leurs, R; Smits, RA A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett 23:2663-70 (2013) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_MOUSE | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44272.75
Organism:
Mus musculus (mouse)
Description:
Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
  
Inhibitor
Name:
BDBM50433359
Synonyms:
CHEMBL2376804
Type:
Small organic molecule
Emp. Form.:
C14H18N6
Mol. Mass.:
270.3329
SMILES:
CNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CC1
Structure:
Search PDB for entries with ligand similarity: