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Target
Sialidase-2
Ligand
BDBM50331675
Substrate
n/a
Meas. Tech.
ChEMBL_960638 (CHEMBL2390091)
IC50
130000±n/a nM
Citation
 Albohy, A; Zhang, Y; Smutova, V; Pshezhetsky, AV; Cairo, CW Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. ACS Med Chem Lett 4:532-7 (2013) [PubMed]  Article 
Target
Name:
Sialidase-2
Synonyms:
Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | NEUR2_HUMAN | Sialidase 2 | Sialidase-2
Type:
PROTEIN
Mol. Mass.:
42256.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960638
Residue:
380
Sequence:
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
  
Inhibitor
Name:
BDBM50331675
Synonyms:
(2R,3R,4S)-3-acetamido-2-((1R,2R)-3-(4-ethoxy-1H-1,2,3-triazol-1-yl)-1,2-dihydroxypropyl)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylate | CHEMBL1289540
Type:
Small organic molecule
Emp. Form.:
C15H22N4O8
Mol. Mass.:
386.3572
SMILES:
CCOc1cn(C[C@@H](O)[C@@H](O)[C@@H]2OC(=C[C@H](O)[C@H]2NC(C)=O)C(O)=O)nn1 |r,c:13|
Structure:
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