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Target
Sialidase-1
Ligand
BDBM50331683
Substrate
n/a
Meas. Tech.
ChEMBL_960639 (CHEMBL2390092)
IC50
>1000000±n/a nM
Citation
 Albohy, A; Zhang, Y; Smutova, V; Pshezhetsky, AV; Cairo, CW Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. ACS Med Chem Lett 4:532-7 (2013) [PubMed]  Article 
Target
Name:
Sialidase-1
Synonyms:
NANH | NEU1 | NEUR1_HUMAN | Sialidase 1
Type:
PROTEIN
Mol. Mass.:
45463.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960639
Residue:
415
Sequence:
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
  
Inhibitor
Name:
BDBM50331683
Synonyms:
(2R,3R,4S)-4-hydroxy-3-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)acetamido)-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate | CHEMBL1289979
Type:
Small organic molecule
Emp. Form.:
C19H22N4O8
Mol. Mass.:
434.4
SMILES:
OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccccc1)C(O)=O |r,c:8|
Structure:
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