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Target
Lysine--tRNA ligase
Ligand
BDBM50434379
Substrate
n/a
Meas. Tech.
ChEMBL_960665 (CHEMBL2390259)
IC50
>20000±n/a nM
Citation
 Biamonte, MA; Wanner, J; Le Roch, KG Recent advances in malaria drug discovery. Bioorg Med Chem Lett 23:2829-43 (2013) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50434379
Synonyms:
CLADOSPORIN
Type:
Small organic molecule
Emp. Form.:
C16H20O5
Mol. Mass.:
292.327
SMILES:
C[C@H]1CCC[C@H](C[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)O1 |r|
Structure:
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