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Target
Calcium/calmodulin-dependent protein kinase type IV
Ligand
BDBM50434485
Substrate
n/a
Meas. Tech.
ChEMBL_961506 (CHEMBL2388364)
IC50
27000±n/a nM
Citation
 Xiao, D; Palani, A; Huang, X; Sofolarides, M; Zhou, W; Chen, X; Aslanian, R; Guo, Z; Fossetta, J; Tian, F; Trivedi, P; Spacciapoli, P; Whitehurst, CE; Lundell, D Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors. Bioorg Med Chem Lett 23:3262-6 (2013) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type IV
Synonyms:
CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN
Type:
PROTEIN
Mol. Mass.:
51919.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459854
Residue:
473
Sequence:
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
  
Inhibitor
Name:
BDBM50434485
Synonyms:
CHEMBL2385543
Type:
Small organic molecule
Emp. Form.:
C34H29ClN4O2
Mol. Mass.:
561.073
SMILES:
Clc1ccc(cc1)-c1cc2Cc3cc(ccc3N(Cc3ccccc3-c3cccnc3)C(=O)c2o1)N1CCNCC1
Structure:
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