Reaction Details Report a problem with these data
Target
Bone morphogenetic protein 4
Ligand
BDBM50261979
Substrate
n/a
Meas. Tech.
ChEMBL_961936 (CHEMBL2390527)
IC50
152±n/a nM
Citation
 Engers, DW; Frist, AY; Lindsley, CW; Hong, CC; Hopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett 23:3248-52 (2013) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein 4
Synonyms:
BMP-2B | BMP4_MOUSE | Bmp-4 | Bmp4 | Bone morphogenetic protein 2B | Dvr-4
Type:
PROTEIN
Mol. Mass.:
46510.27
Organism:
Mus musculus
Description:
ChEMBL_107597
Residue:
408
Sequence:
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
  
Inhibitor
Name:
BDBM50261979
Synonyms:
5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | CHEMBL502351
Type:
Small organic molecule
Emp. Form.:
C22H16N4O
Mol. Mass.:
352.3886
SMILES:
COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: