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Target
Quinolone resistance protein NorA
Ligand
BDBM50434974
Substrate
n/a
Meas. Tech.
ChEMBL_961221 (CHEMBL2390113)
IC50
3800±n/a nM
Citation
 Sabatini, S; Gosetto, F; Iraci, N; Barreca, ML; Massari, S; Sancineto, L; Manfroni, G; Tabarrini, O; Dimovska, M; Kaatz, GW; Cecchetti, V Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance. J Med Chem 56:4975-89 (2013) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50434974
Synonyms:
CHEMBL2385690
Type:
Small organic molecule
Emp. Form.:
C31H35N3O2
Mol. Mass.:
481.6285
SMILES:
CCCOc1ccc(cc1)-c1cc(OCCN2CCN(Cc3ccccc3)CC2)c2ccccc2n1
Structure:
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