Reaction Details Report a problem with these data
Target
Glutamyl endopeptidase
Ligand
BDBM50435118
Substrate
n/a
Meas. Tech.
ChEMBL_965125 (CHEMBL2393667)
Ki
12900±n/a nM
Citation
 Burchacka, E; Skorenski, M; Sienczyk, M; Oleksyszyn, J Phosphonic analogues of glutamic acid as irreversible inhibitors of Staphylococcus aureus endoproteinase GluC: an efficient synthesis and inhibition of the human IgG degradation. Bioorg Med Chem Lett 23:1412-5 (2013) [PubMed]  Article 
Target
Name:
Glutamyl endopeptidase
Synonyms:
SSPA_STAAU | sspA
Type:
PROTEIN
Mol. Mass.:
36315.14
Organism:
Staphylococcus aureus
Description:
ChEMBL_965125
Residue:
336
Sequence:
MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA
  
Inhibitor
Name:
BDBM50435118
Synonyms:
CHEMBL2391721
Type:
Small organic molecule
Emp. Form.:
C29H38N3O11P
Mol. Mass.:
635.5993
SMILES:
C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)OC(C)(C)C)C(=O)NC(CCC(O)=O)P(=O)(Oc1ccccc1)Oc1ccccc1 |r|
Structure:
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