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Target
Urea transporter 1
Ligand
BDBM50394962
Substrate
n/a
Meas. Tech.
ChEMBL_964778 (CHEMBL2394862)
IC50
11±n/a nM
Citation
 Liu, Y; Esteva-Font, C; Yao, C; Phuan, PW; Verkman, AS; Anderson, MO 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorg Med Chem Lett 23:3338-41 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
HUT11 | JK | RACH1 | SLC14A1 | Solute carrier family 14 member 1 | UT1 | UT1_HUMAN | UTE | Urea transporter, erythrocyte
Type:
PROTEIN
Mol. Mass.:
42529.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107607
Residue:
389
Sequence:
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
  
Inhibitor
Name:
BDBM50394962
Synonyms:
CHEMBL1394231
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2S3
Mol. Mass.:
455.576
SMILES:
CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12
Structure:
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