Reaction Details Report a problem with these data
Target
Urea transporter 1
Ligand
BDBM50435308
Substrate
n/a
Meas. Tech.
ChEMBL_964780 (CHEMBL2394864)
IC50
38±n/a nM
Citation
 Liu, Y; Esteva-Font, C; Yao, C; Phuan, PW; Verkman, AS; Anderson, MO 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorg Med Chem Lett 23:3338-41 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | Solute carrier family 14 member 1 | UT-B | UT1_MOUSE | Urea transporter B | Urea transporter, erythrocyte
Type:
PROTEIN
Mol. Mass.:
42130.98
Organism:
Mus musculus
Description:
ChEMBL_964780
Residue:
384
Sequence:
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
  
Inhibitor
Name:
BDBM50435308
Synonyms:
CHEMBL2391344
Type:
Small organic molecule
Emp. Form.:
C21H17F2N5O2S3
Mol. Mass.:
505.584
SMILES:
Cc1csc(CNc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(cc2)C(C)(F)F)c1
Structure:
Search PDB for entries with ligand similarity: