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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50435331
Substrate
n/a
Meas. Tech.
ChEMBL_964802 (CHEMBL2395048)
IC50
>100000±n/a nM
Citation
 Kelly, NM; Wellejus, A; Elbrønd-Bek, H; Weidner, MS; Jørgensen, SH Synthesis and biological evaluation of Esaprazole analogues showings1 binding and neuroprotective properties in vitro. Bioorg Med Chem 21:3334-47 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50435331
Synonyms:
CHEMBL2391367
Type:
Small organic molecule
Emp. Form.:
C15H27N3O2
Mol. Mass.:
281.3938
SMILES:
CCC(=O)N1CCN(CC(=O)NC2CCCCC2)CC1
Structure:
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