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Target
Tyrosine-protein phosphatase YopH
Ligand
BDBM50435419
Substrate
n/a
Meas. Tech.
ChEMBL_965525 (CHEMBL2395473)
IC50
9000±n/a nM
Citation
 Martins, PG; Menegatti, AC; Chiaradia-Delatorre, LD; de Oliveira, KN; Guido, RV; Andricopulo, AD; Vernal, J; Yunes, RA; Nunes, RJ; Terenzi, H Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors. Eur J Med Chem 64:35-41 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase YopH
Synonyms:
YOPH_YEREN | yop51 | yopH
Type:
PROTEIN
Mol. Mass.:
50951.99
Organism:
Yersinia enterocolitica
Description:
ChEMBL_965525
Residue:
468
Sequence:
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
  
Inhibitor
Name:
BDBM50435419
Synonyms:
CHEMBL2392065
Type:
Small organic molecule
Emp. Form.:
C18H18N2O5S
Mol. Mass.:
374.411
SMILES:
Oc1c2C3OC(C=C3)c2c(O)n1-c1ccc(cc1)S(=O)(=O)N1CCCC1 |c:6|
Structure:
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