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Target
Dual specificity protein phosphatase 15
Ligand
BDBM50436357
Substrate
n/a
Meas. Tech.
ChEMBL_966892 (CHEMBL2401183)
IC50
4600±n/a nM
Citation
 He, Y; Liu, S; Menon, A; Stanford, S; Oppong, E; Gunawan, AM; Wu, L; Wu, DJ; Barrios, AM; Bottini, N; Cato, AC; Zhang, ZY A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem 56:4990-5008 (2013) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 15
Synonyms:
C20orf57 | DUS15_HUMAN | DUSP15 | VH1-related member Y | VHY | Vaccinia virus VH1-related dual-specific protein phosphatase Y
Type:
PROTEIN
Mol. Mass.:
31893.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107613
Residue:
295
Sequence:
MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR
  
Inhibitor
Name:
BDBM50436357
Synonyms:
CHEMBL2396719
Type:
Small organic molecule
Emp. Form.:
C28H20ClNO6
Mol. Mass.:
501.915
SMILES:
OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1
Structure:
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