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Target
Thromboxane A2 receptor
Ligand
BDBM50436759
Substrate
n/a
Meas. Tech.
ChEMBL_971636 (CHEMBL2404055)
IC50
5540±n/a nM
Citation
 Bambi-Nyanguile, SM; Hanson, J; Ooms, A; Alpan, L; Kolh, P; Dogné, JM; Pirotte, B Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists. Eur J Med Chem 65:32-40 (2013) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50436759
Synonyms:
CHEMBL2402414
Type:
Small organic molecule
Emp. Form.:
C18H18IN3O4S
Mol. Mass.:
499.323
SMILES:
CC(C)(C)NC(=O)NS(=O)(=O)c1cc(ccc1Oc1ccc(I)cc1)C#N
Structure:
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