Reaction Details Report a problem with these data
Target
Kallikrein-14
Ligand
BDBM32709
Substrate
n/a
Meas. Tech.
ChEMBL_973067 (CHEMBL2412648)
IC50
1290±n/a nM
Citation
 Tan, X; Furio, L; Reboud-Ravaux, M; Villoutreix, BO; Hovnanian, A; El Amri, C 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett 23:4547-51 (2013) [PubMed]  Article 
Target
Name:
Kallikrein-14
Synonyms:
KLK-L6 | KLK14 | KLK14_HUMAN | KLKL6 | Kallikrein 14 | Kallikrein-14 | Kallikrein-like protein 6 | hK14
Type:
PROTEIN
Mol. Mass.:
29136.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282452
Residue:
267
Sequence:
MSLRVLGSGTWPSAPKMFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK
  
Inhibitor
Name:
BDBM32709
Synonyms:
(5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-methylphenyl)methanone | (5-azanyl-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-methylphenyl)methanone | 1-(4-methylbenzoyl)-3-(3-pyridinyl)-1H-1,2,4-triazol-5-amine | MLS000537840 | SMR000144080 | [5-amino-3-(3-pyridinyl)-1,2,4-triazol-1-yl]-(4-methylphenyl)methanone | [5-amino-3-(3-pyridyl)-1,2,4-triazol-1-yl]-(p-tolyl)methanone | cid_970375
Type:
Small organic molecule
Emp. Form.:
C15H13N5O
Mol. Mass.:
279.2966
SMILES:
Cc1ccc(cc1)C(=O)n1nc(nc1N)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: