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Target
Heme oxygenase 1
Ligand
BDBM50240895
Substrate
n/a
Meas. Tech.
ChEMBL_976175 (CHEMBL2415824)
IC50
2500±n/a nM
Citation
 Salerno, L; Pittalà, V; Romeo, G; Modica, MN; Siracusa, MA; Di Giacomo, C; Acquaviva, R; Barbagallo, I; Tibullo, D; Sorrenti, V Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. Bioorg Med Chem 21:5145-53 (2013) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50240895
Synonyms:
2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | CHEMBL162549
Type:
Small organic molecule
Emp. Form.:
C11H9N3O3
Mol. Mass.:
231.2075
SMILES:
[O-][N+](=O)c1ccc(cc1)C(=O)Cn1ccnc1
Structure:
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