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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50439200
Substrate
n/a
Meas. Tech.
ChEMBL_978590 (CHEMBL2422107)
IC50
700±n/a nM
Citation
 Ramsbeck, D; Buchholz, M; Koch, B; Böhme, L; Hoffmann, T; Demuth, HU; Heiser, U Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold. J Med Chem 56:6613-25 (2013) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50439200
Synonyms:
CHEMBL2418775
Type:
Small organic molecule
Emp. Form.:
C19H18N4O2S
Mol. Mass.:
366.437
SMILES:
COc1cccc(CCc2nnc(s2)-c2ccc3nc[nH]c3c2)c1OC
Structure:
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